Relative Telomere Length and Cardiovascular Risk Factors
نویسندگان
چکیده
منابع مشابه
Inflammation and not cardiovascular risk factors is associated with short leukocyte telomere length in 13- to 16-year-old adolescents.
OBJECTIVE Short leukocyte telomere length (LTL) is associated with cardiovascular (CV) disease in adulthood. However, the biological basis of this association remains unclear. We sought to define early determinants of the association between CV disease and LTL in an adolescent population. METHODS AND RESULTS One thousand eighty adolescents, aged 13 to 16 years and participating in the Ten Tow...
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During breast cancer progression, a substantial increase in chromosomal aberrations is observed in the transition from ductal hyperplasia to carcinoma in situ. Telomeres are essential structures to chromosomal integrity. Consequently, telomere dysfunction, which leads to genomic instability, is hypothesized to play a causal role in the progression of breast cancer. However, the few epidemiologi...
متن کاملLeucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis
OBJECTIVE To assess the association between leucocyte telomere length and risk of cardiovascular disease. DESIGN Systematic review and meta-analysis. DATA SOURCES Studies published up to March 2014 identified through searches of Medline, Web of Science, and Embase. ELIGIBILITY CRITERIA Prospective and retrospective studies that reported on associations between leucocyte telomere length an...
متن کاملInsulin-like growth factors and leukocyte telomere length: the cardiovascular health study.
The insulin-like growth factor (IGF) axis may affect immune cell replicative potential and telomere dynamics. Among 551 adults 65 years and older, leukocyte telomere length (LTL), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor-binding proteins 1 and 3 (IGFBP-1, IGFBP-3) were measured. Multivariate linear regression was used to model the association of LTL with IGF-1 and IG...
متن کاملTelomere length, cardiovascular risk and arteriosclerosis in human kidneys: an observational cohort study
BACKGROUND Replicative senescence, associated with telomere shortening, plays an important role in aging and cardiovascular disease. The relation between telomere length, cardiovascular risk, and renal disease is unknown. METHODS Our study consisted of a cohort of 257 kidney donors for transplantation, divided into a test and a validation cohort. We used quantitative RT-PCR to measure relativ...
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ژورنال
عنوان ژورنال: Biomolecules
سال: 2019
ISSN: 2218-273X
DOI: 10.3390/biom9050192